SPECT imaging of the α4β2 nicotinic receptor using (5-123I)A85380

被引：3

作者：

Pimlorr, Sally L. ^{[1
]}

Piggott, Margaret

Patterson, James

Cavanagh, Jonathan

Wyper, David J.

机构：

[1] Univ Glasgow, Dept Clin Phys, Glasgow, Lanark, Scotland

[2] Newcastle Gen Hosp, Inst Hlth & Aging, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

[3] So Gen Hosp, Inst Neurol Sci, Glasgow G51 4TF, Lanark, Scotland

[4] Univ Glasgow, Sackler Inst Psychobiol Res, Glasgow G12 8QQ, Lanark, Scotland

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2007年 / 50卷 / 5-6期

关键词：

nicotinic; receptors; 5-IA85380; SPECT; imaging;

D O I：

10.1002/jlcr.1192

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to image nAChR density in vivo in humans, [5- I-123] -iodo-3-[2(S)-2-azetidinylmethoxylpyridine ([5- I-123]A85380) has been developed as a SPECT imaging tracer. This article outlines the radiochemical synthesis, in vitro validation in human post-mortem tissue and some initial in vivo clinical studies using the ligand [5-I-123/125]A85380. Limitations of the usefulness of the tracer for routine clinical use are also discussed. Copyright (c) 2007 John Wiley & Sons, Ltd.

引用

页码：350 / 353

页数：4

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Zoghbi, SS
Fujita, M
Rajeevan, N
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Innis, RB
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