SPECT imaging of the α4β2 nicotinic receptor using (5-123I)A85380

被引：3
|
作者：
Pimlorr, Sally L. [1 ]
Piggott, Margaret
Patterson, James
Cavanagh, Jonathan
Wyper, David J.
机构：
[1] Univ Glasgow, Dept Clin Phys, Glasgow, Lanark, Scotland
[2] Newcastle Gen Hosp, Inst Hlth & Aging, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England
[3] So Gen Hosp, Inst Neurol Sci, Glasgow G51 4TF, Lanark, Scotland
[4] Univ Glasgow, Sackler Inst Psychobiol Res, Glasgow G12 8QQ, Lanark, Scotland
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2007年 / 50卷 / 5-6期
关键词：
nicotinic; receptors; 5-IA85380; SPECT; imaging;
D O I：
10.1002/jlcr.1192
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
In order to image nAChR density in vivo in humans, [5- I-123] -iodo-3-[2(S)-2-azetidinylmethoxylpyridine ([5- I-123]A85380) has been developed as a SPECT imaging tracer. This article outlines the radiochemical synthesis, in vitro validation in human post-mortem tissue and some initial in vivo clinical studies using the ligand [5-I-123/125]A85380. Limitations of the usefulness of the tracer for routine clinical use are also discussed. Copyright (c) 2007 John Wiley & Sons, Ltd.
引用
收藏
页码：350 / 353
页数：4
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