Mitochondrial DNA Copy Number Variations in Gastrointestinal Tract Cancers: Potential Players

被引：0
|
作者：
Alikhani, Mehdi [1 ]
Touati, Eliette [2 ]
Karimipoor, Morteza [3 ]
Vosough, Massoud [4 ]
Mohammadi, Marjan [1 ]
机构：
[1] Pasteur Inst Iran, Biotechnol Res Ctr, Med Biotechnol Dept, Tehran, Iran
[2] CNRS, UMR 2001, Inst Pasteur, Dept Microbiol,Unit Helicobacter Pathogenesis, 25-28 Rue Dr Roux, F-75724 Paris 15, France
[3] Pasteur Inst Iran, Biotechnol Res Ctr, Mol Med Dept, Tehran, Iran
[4] ACECR, Royan Inst Stem Cell Biol & Technol, Cell Sci Res Ctr, Dept Regenerat Med, Tehran, Iran
来源：
JOURNAL OF GASTROINTESTINAL CANCER | 2022年 / 53卷 / 03期
关键词：
mtDNA copy number; Biomarker; Cancer; Gastrointestinal tract cancers; Causes; OXIDATIVE STRESS; TRANSCRIPTION FACTOR; PERIPHERAL-BLOOD; TELOMERE LENGTH; D-LOOP; TARGETING MITOCHONDRIA; MOLECULAR-MECHANISMS; HELICOBACTER-PYLORI; POLYMERASE-GAMMA; AIR-POLLUTION;
D O I：
10.1007/s12029-021-00707-w
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Alterations of mitochondria have been linked to several cancers. Also, the mitochondrial DNA copy number (mtDNA-CN) is altered in various cancers, including gastrointestinal tract (GIT) cancers, and several research groups have investigated its potential as a cancer biomarker. However, the exact causes of mtDNA-CN variations are not yet revealed. This review discussed the conceivable players in this scheme, including reactive oxygen species (ROS), mtDNA genetic variations, DNA methylation, telomere length, autophagy, immune system activation, aging, and infections, and discussed their possible impact in the initiation and progression of cancer. By further exploring such mechanisms, mtDNA-CN variations may be effectively utilized as cancer biomarkers and provide grounds for developing novel cancer therapeutic agents.
引用
收藏
页码：770 / 781
页数：12
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