In vivo and in vitro effects of a protease inhibitor (E-64) on cell division of Xenopus eggs

被引：1

作者：

Ishii, T ^{[1
]}

Aoki, T ^{[1
]}

Hosoyama, Y ^{[1
]}

Miyata, S ^{[1
]}

机构：

[1] Nihon Univ, Coll Humanities & Sci, Dept Chem, Setagaya Ku, Tokyo 156, Japan

来源：

ZOOLOGICAL SCIENCE | 2000年 / 17卷 / 09期

关键词：

D O I：

10.2108/zsj.17.1283

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

Microinjection of E-64 into single blastomeres of Xenopus embryos at the 2-cell stage arrested cell division. In vitro treatment of cultured individual cells at the blastular embryonic stage with E-64 c also arrested the cleavages. We examined the effects of E-64 on the proteasome and calcium-activated protease in Xenopus embryos in vitro. E-64 inhibited calpain-like protease activity. Calpain-like protease activity was stimulated during cleavage. These results indicated that a calpain-like protease might be involved in the cell division of early Xenopus embryos.

引用

页码：1283 / 1287

页数：5

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