Biomimetic Chromatography to Accelerate Drug Discovery: Part II

被引：0
|
作者：
Valko, Klara [1 ,2 ]
机构：
[1] Biomimet Chromatog Ltd, Stevenage, Herts, England
[2] UCL, Sch Pharm, London, England
来源：
LC GC NORTH AMERICA | 2018年 / 36卷 / 08期
关键词：
LEAD OPTIMIZATION; PHARMACOKINETICS; EFFICIENCY;
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The biomimetic gradient retention time measurements on C18, immobilized artificial membrane (IAM), human serum albumin (HSA), and acid-glycoprotein (AGP) stationary phases can be used to characterize compounds partitioning into phospholipids and proteins. The data obtained can then be used in equations to estimate the in vivo plasma-tissue distribution of the compounds measured. The plasma protein binding, brain tissue binding, and in vivo drug efficiency can also be calculated using the biomimetic chromatographic data.
引用
收藏
页码：520 / 526
页数：7
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