Biomimetic Chromatography to Accelerate Drug Discovery: Part II

被引：0
|
作者：
Valko, Klara [1 ,2 ]
机构：
[1] Biomimet Chromatog Ltd, Stevenage, Herts, England
[2] UCL, Sch Pharm, London, England
来源：
LC GC NORTH AMERICA | 2018年 / 36卷 / 08期
关键词：
LEAD OPTIMIZATION; PHARMACOKINETICS; EFFICIENCY;
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The biomimetic gradient retention time measurements on C18, immobilized artificial membrane (IAM), human serum albumin (HSA), and acid-glycoprotein (AGP) stationary phases can be used to characterize compounds partitioning into phospholipids and proteins. The data obtained can then be used in equations to estimate the in vivo plasma-tissue distribution of the compounds measured. The plasma protein binding, brain tissue binding, and in vivo drug efficiency can also be calculated using the biomimetic chromatographic data.
引用
收藏
页码：520 / 526
页数：7
相关论文
共 50 条
  • [1] Biomimetic Chromatography to Accelerate Drug Discovery: Part 1
    Valko, Klara
    LC GC EUROPE, 2018, 31 (02) : 62 - 72
  • [2] Biomimetic Chromatography to Accelerate Drug Discovery: Part I
    Valko, Klara
    LC GC NORTH AMERICA, 2018, 36 (06) : 397 - 405
  • [3] Biomimetic Chromatography to Accelerate Drug Discovery: Part 2
    Valko, Klara
    LC GC EUROPE, 2018, 31 (05) : 250 - 257
  • [4] Biomimetic Chromatography A Useful Tool in the Drug Discovery Process
    Chrysanthakopoulos, Marios
    Tsopelas, Fotios
    Tsantili-Kakoulidou, Anna
    ADVANCES IN CHROMATOGRAPHY, VOL 51, 2013, 51 : 91 - 125
  • [5] Development of biomimetic phospholipid membrane chromatography for drug discovery: A comprehensive review
    Wang, Jincai
    Guo, Jialiang
    Xu, Dongsheng
    He, Lixiao
    Qu, Jia-Huan
    Wang, Qiqin
    Crommen, Jacques
    Jiang, Zhengjin
    TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2024, 171
  • [6] Advancement of Technology for Drug Discovery and Development - Part II
    Niu, Bing
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2020, 20 (01) : 3 - 3
  • [7] Protein Activation in Drug Discovery - Part-II
    Chen, Qi
    Hao, Junliang
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2019, 19 (26) : 2377 - 2377
  • [8] Multi-target Drug Discovery - Part II
    Chen, Jia-Nian
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2017, 17 (28) : 3081 - 3083
  • [9] Part II: new frontiers in antibacterial drug discovery
    Moloney, Mark G.
    FUTURE MEDICINAL CHEMISTRY, 2016, 8 (10) : 1015 - 1016
  • [10] Transgenic parasites accelerate drug discovery
    Rodriguez, Ana
    Tarleton, Rick L.
    TRENDS IN PARASITOLOGY, 2012, 28 (03) : 90 - 92
12345