The Functions of Selenium and Selenoproteins Relating to the Liver Diseases

被引：17
|
作者：
Shang, Ningning [1 ,2 ,3 ]
Wang, Xiaofeng [2 ]
Shu, Qingming [4 ]
Wang, Hao [1 ,3 ]
Zhao, Lina [2 ]
机构：
[1] Natl Ctr Nanosci & Technol NCNST, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
[2] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, IHEP, Beijing 100049, Peoples R China
[3] UCAS, Beijing 100049, Peoples R China
[4] Chinese Peoples Armed Police Forces, Dept Pathol, Gen Hosp, Beijing 100039, Peoples R China
来源：
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2019年 / 19卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Selenium; Selenoproteins; Liver Diseases; ROS; THIOREDOXIN REDUCTASE 1; DEPENDENT GLUTATHIONE-PEROXIDASE; BETA-ELIMINATION REACTIONS; FOOD-CHAIN SELENIUM; OXIDATIVE STRESS; TISSUE DISTRIBUTION; MEDIATED APOPTOSIS; INORGANIC SELENIUM; CANCER STATISTICS; SODIUM SELENITE;
D O I：
10.1166/jnn.2019.16287
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Selenium is an important trace element. Many studies have proved that selenium can protect liver tissues by reducing response of immune inflammation and inducing high levels of ROS to promote tumor apoptosis. It can also participate in metabolism and involve in expression of selenoproteins. Selenoproteins also play a key role in liver diseases with regulating ROS and relating factors. In this review, we summarized the metabolic pathways of selenium intake and their bio-functions on liver diseases (Hepatoma, Cirrhosis and hepatitis). Moreover, the related molecular mechanisms are analyzed and discussed. Selenoproteins may be a promising target for liver diseases treatment.
引用
收藏
页码：1875 / 1888
页数：14
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