Effect of amiodarone on thermotolerance and Hsp104p synthesis in the yeast Saccharomyces cerevisiae

被引：9
|
作者：
Fedoseeva, I. V. [1 ]
Pjatricas, D. V. [1 ]
Varakina, N. N. [1 ]
Rusaleva, T. M. [1 ]
Stepanov, A. V. [1 ]
Rikhvanov, E. G. [1 ]
Borovskii, G. B. [1 ]
Voinikov, V. K. [1 ]
机构：
[1] Russian Acad Sci, Siberian Div, Siberian Inst Plant Physiol & Biochem, Irkutsk 664033, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2012年 / 77卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
amiodarone; Saccharomyces cerevisiae; thermotolerance; Hsp104p; mitochondrion; SHOCK-PROTEIN RESPONSE; PROGRAMMED CELL-DEATH; HEAT-SHOCK; MITOCHONDRIA; MECHANISM; PLANTS; EXPRESSION; APOPTOSIS; GLUCOSE; STRESS;
D O I：
10.1134/S0006297912010099
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Amiodarone (AMD) is known to induce a transient increase in cytosolic Ca2+ level in cells of the yeast Saccharomyces cerevisiae. In the present study the effect of AMD on the thermotolerance and Hsp104p synthesis of the yeast was studied. AMD induced Hsp104p synthesis and increased survival of the yeast after a severe heat shock (50A degrees C). The development of thermotolerance to a considerable extent depended on the presence of Hsp104p. The same effect was achieved by treatment with the classical uncoupler CCCP, which is also known to increase the cytosolic Ca2+ level. It is supposed that the change in intracellular Ca2+ concentration plays an important role in activation of the HSP104 gene expression and in increasing the thermotolerance of the yeast. The possible link between mitochondrial activity and calcium homeostasis is discussed.
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收藏
页码：78 / 86
页数：9
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