Neuroendocrinology of neurodegenerative diseases - Insights from transgenic mouse models

被引：16

作者：

de Aguilar, JLG ^{[1
]}

René, F ^{[1
]}

Dupuis, L ^{[1
]}

Loeffler, JP ^{[1
]}

机构：

[1] Univ Strasbourg, Lab Signalisat Mol & Neurodegenerescence, EA 3433, FR-67085 Strasbourg, France

来源：

NEUROENDOCRINOLOGY | 2003年 / 78卷 / 05期

关键词：

Alzheimer's disease; neurodegenerative diseases; Parkinson's disease; amyotrophic lateral sclerosis; THYROTROPIN-RELEASING-HORMONE; AMYOTROPHIC-LATERAL-SCLEROSIS; PITUITARY-ADRENAL AXIS; ESTROGEN REPLACEMENT THERAPY; SUPEROXIDE-DISMUTASE GENE; MOTOR-NEURON DISEASE; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; CEREBROSPINAL-FLUID; OXIDATIVE STRESS;

D O I：

10.1159/000074445

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The nervous system plays a key role in the regulation of neuroendocrine axes and, in turn, the released neurohormones modulate the activity of different brain regions. Neurodegenerative diseases, which are known to affect specific neuronal populations, may provoke neuroendocrine dysfunctions that alter the intimate relationship between both systems. In addition, these modifications may influence the progression of the neurodegenerative process. In the present review, we summarise some of the endocrine changes characterising three major neurodegenerative diseases: Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Special attention is focused on the contribution of disease transgenic models to elucidate such alterations. Copyright (C) 2003 S. Karger AG, Basel.

引用

页码：244 / 252

页数：9

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