Cooperative anti-Candida effects of lactoferrin or its peptides in combination with azole antifungal agents

被引：97
|
作者：
Wakabayashi, H [1 ]
Abe, S [1 ]
Okutomi, T [1 ]
Tansho, S [1 ]
Kawase, K [1 ]
Yamaguchi, H [1 ]
机构：
[1] TEIKYO UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,TOKYO 173,JAPAN
来源：
MICROBIOLOGY AND IMMUNOLOGY | 1996年 / 40卷 / 11期
关键词：
lactoferrin; Lactoferricin(R); azole antifungal agents; Candida albicans;
D O I：
10.1111/j.1348-0421.1996.tb01147.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The effects of lactoferrin (LF), an antimicrobial protein secreted in body fluids, and its peptides in combination with azole antifungal agents were investigated by the micro-broth-dilution method in a study of Candida albicans, In the case of LF, its pepsin hydrolysate (LFhyd) or the LF-derived antimicrobial peptide Lactoferricin(R) B (LF-B), the concentrations required to inhibit the growth of Candida decreased in the presence of relatively low concentrations of clotrimazole (CTZ), The minimum inhibitory concentration (MIC) of all azole antifungal agents tested was reduced by 1/4-1/16 in the presence of a sub-MIG level of each of these LF-related substances. Polyene and fluoropyrimidine antifungal agents did not show such a combined effect with these LF-related substances. The anti-Candida activity of LF or LF-B in combination with GTZ was shown to be synergistic by checkerboard analysis. These results indicate that LF-related substances function cooperatively with azole antifungal agents against C. albicans.
引用
收藏
页码：821 / 825
页数：5
相关论文
共 50 条
  • [41] Comparison of the Effects of Azole Antifungal Agents on the Anticoagulant Activity of Warfarin
    Yamamoto, Hiroki
    Habu, Yasushi
    Yano, Ikuko
    Ozaki, Junko
    Kimura, Yoshihiko
    Sato, Eriko
    Shida, Ayumi
    Fukatsu, Sachio
    Matsubara, Kazuo
    [J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2014, 37 (12) : 1990 - 1993
  • [42] Analysis of the anti-Candida activity of tricyclic antidepressants in association with amphotericin B and their antifungal mechanisms
    Cabral, Vitoria Pessoa de Farias
    Rodrigues, Daniel Sampaio
    Sa, Livia Gurgel do Amaral Valente
    Moreira, Lara Elloyse Almeida
    da Silva, Cecilia Rocha
    de Andrade Neto, Joao Batista
    da Costa, erica Rayanne Mota
    Ferreira, Thais Lima
    de Oliveira, Leilson Carvalho
    de Souza, Beatriz Oliveira
    Cavalcanti, Bruno Coelho
    Magalhaes, Islay Lima
    de Moraes, Manoel Odorico
    Nobre Junior, Helio Vitoriano
    [J]. BRAZILIAN JOURNAL OF MICROBIOLOGY, 2024,
  • [43] ANTI-CANDIDA ACTIVITY OF CLOTRIMAZOLE IN COMBINATION WITH DIOCTYL SODIUM SULFOSUCCINATE AND OTHER SURFACTANTS
    IWATA, K
    YAMAGUCHI, H
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1977, 12 (02) : 206 - 212
  • [44] Effects of Antifungal Agents Alone and in Combination Against Candida glabrata Strains Susceptible or Resistant to Fluconazole
    Alves, Izabel Almeida
    Bandeira, Laissa Arevalo
    Nunes Mario, Debora Alves
    Denardi, Laura Bedin
    Neves, Louise Vignoles
    Santurio, Janio Morais
    Alves, Sydney Hartz
    [J]. MYCOPATHOLOGIA, 2012, 174 (03) : 215 - 221
  • [45] Effects of Antifungal Agents Alone and in Combination Against Candida glabrata Strains Susceptible or Resistant to Fluconazole
    Izabel Almeida Alves
    Laíssa Arévalo Bandeira
    Débora Alves Nunes Mario
    Laura Bedin Denardi
    Louise Vignoles Neves
    Janio Morais Santurio
    Sydney Hartz Alves
    [J]. Mycopathologia, 2012, 174 : 215 - 221
  • [46] Anti-Candida Potential of Peptides from Immature and Ripe Fruits of Capsicum chinense Jacq
    Marilucia C. Ribeiro
    Rodrigo S. Gebara
    Gabriel B. Taveira
    André de O. Carvalho
    Rosana Rodrigues
    Erica O. Mello
    Celso  S. Nagano
    Renata  P. Chaves
    Valdirene M. Gomes
    [J]. Probiotics and Antimicrobial Proteins, 2023, 15 : 1124 - 1136
  • [47] Anti-Candida Potential of Peptides from Immature and Ripe Fruits of Capsicum chinense Jacq
    Ribeiro, Marilucia C.
    Gebara, Rodrigo S.
    Taveira, Gabriel B.
    Carvalho, Andre de O.
    Rodrigues, Rosana
    Mello, Erica O.
    Nagano, Celso S.
    Chaves, Renata P.
    Gomes, Valdirene M.
    [J]. PROBIOTICS AND ANTIMICROBIAL PROTEINS, 2023, 15 (05) : 1124 - 1136
  • [48] Clinical analysis of the effects of azole antifungal agents on the anticoagulant activity of warfarin
    Chen, Wenjun
    Wu, Tingting
    Jiang, Shaojun
    Lv, Meina
    Fu, Jinglan
    Xia, Xiaotong
    Zhang, Jinhua
    [J]. MEDICINE, 2020, 99 (46) : E22987
  • [49] Comparison of anti-Candida activity of thyme, pennyroyal, and lemon essential oils versus antifungal drugs against Candida species
    Omran, Saeid Mahdavi
    Esmailzadeh, Seddighe
    [J]. JUNDISHAPUR JOURNAL OF MICROBIOLOGY, 2009, 2 (02) : 53 - 60
  • [50] Synergistic Antifungal Effect of Lactoferrin with Azole Antifungals against Candida albicans and a Proposal for a New Treatment Method for Invasive Candidiasis
    Kobayashi, Tsutomu
    Kakeya, Hiroshi
    Miyazaki, Taiga
    Izumikawa, Koichi
    Yanagihara, Katsunori
    Ohno, Hideaki
    Yamamoto, Yoshihiro
    Tashiro, Takayoshi
    Kohno, Shigeru
    [J]. JAPANESE JOURNAL OF INFECTIOUS DISEASES, 2011, 64 (04) : 292 - 296
12345