EFFICIENT SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 2-(3-ARYL [1,8] NAPHTHYRIDIN-2-YL)-2,3-DIHYDRO-1H-BENZO [de] ISOQUINOLINE-1,3-DIONES

被引：0
|
作者：
Sakram, B. [1 ]
Ashok, K. [1 ]
Sonyanaik, B. [1 ]
Rambabu, S. [1 ]
机构：
[1] Osmania Univ, Dept Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2014年 / 24卷 / 02期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, rapid and efficient protocol for the synthesis of 2-(3-aryl [1,8] naphthyridin-2-yl)-2,3-dihydro-1H-benzo[de] isoquinoline-1,3-diones 3 has been achieved by the reaction of 2-amino-3-aryl-1,8-naphthyridines 1 with 1,8-naphthalic anhydride 2 in the presence of catalytic amount of DMF in combination with microwave irradiation/in the presence of catalytic amount of PTSA by grinding in a mortar with pestle. The products are obtained in excellent yields with high purity. The structures of the compounds 3 were assigned on the basis of their spectral (IR, H-1 NMR and MS) and analytical data and screened for their antibacterial activity.
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页码：185 / 188
页数：4
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