The characterization of a novel V1b antagonist lead series

被引：3
|
作者：
Smethurst, Chris A. [1 ]
Borthwick, Jennifer A. [1 ]
Gaines, Simon [1 ]
Watson, Steve [1 ]
Green, Andrew [1 ]
Schulz, Mark J.
Burton, George
Buson, Alberto A. [2 ]
Arban, Roberto [2 ]
机构：
[1] GlaxoSmithKline Res & Dev Ltd, Harlow, Essex, England
[2] GlaxoSmithKline Res & Dev Ltd, Verona, Italy
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 01期
关键词：
Vasopressin; Anxiety; Depression; VASOPRESSIN; STRESS;
D O I：
10.1016/j.bmcl.2010.11.061
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The SAR around a V1b antagonist HTS hit 3 was explored to produce a series of thiazole sulfonamides as a lead series with selectivity over the related V1 and oxytocin receptors. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：92 / 96
页数：5
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