Thiourea derivatives of α-aminoacids.: Synthesis and characterization of Ni(II), Cu(II) and Pt(II) complexes with L-valinate derivatives.: Antifungal activity

The preparation of metal complexes with 2-[(3,3'-diethylthioureido)phenylmethylamino]-3-methylbutyric acid methyl ester, Hetv, or 3-methyl-2'-{[morpholine-4-carbothioylimino)phenylmethyl]amino}-butyric acid methyl ester, Hmtv, has been achieved. The complexes obtained with formulae of Ni(etv)(2), Cu(mtv)(2).2H(2)O and Pt(Hmtv)Cl-2, were studied and characterized by elemental analysis, electrical conductivity in solution, IR and UV-VIS spectra, FAB+ and electron impact (EI) mass spectrometry, H-1- and C-13-NMR, ESR, magnetic susceptibility, atomic absorption spectrometry and thermal analysis. Their antifungal activity was studied against the plant pathogenic fungi Colletotrichum fragariae, Rhizoctonia solani and Phoma betae. (C) 1998 Elsevier Science Inc. All rights reserved.