A glycosidic isoflavonoid from Viola hondoensis W.!BECKER et H.!BOISSIEU (Violaceae), and its effect on the expression of matrix metalloproteinase-1 caused by ultraviolet irradiation in cultured human skin fibroblasts

被引:15
|
作者
Moon, HI [1 ]
Lee, J
Zee, OP
Chung, JH
机构
[1] Seoul Natl Univ, Coll Med, Dept Dermatol, Seoul 110744, South Korea
[2] Seoul Natl Univ Hosp, Clin Res Inst, Seoul 110744, South Korea
[3] Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea
[4] Sungkyunkwan Univ, Coll Pharm, Suwon 440746, South Korea
关键词
Viola hondoensis; tectoridin-4 '-O-beta-D-glucoside; matrix metalloproteinase; human skin fibroblasts;
D O I
10.1248/bpb.28.1123
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Isolation of the ethyl acetate soluble fraction from aerial parts of Viola hondoensis W. BECKER et H. BOISSIEU yielded one major isoflavonoid glycoside, tectoridin-4'-O-beta-D-glucoside. The structure of the compound was certainly determined by-chemical analyses, as well as 1D- and 2D-NMR spectroscopy. The compound exhibited potent inhibitory activity against the expression of matrix metalloproteinase-1 caused by UV-irradiation in cultured human skin fibroblasts.
引用
收藏
页码:1123 / 1125
页数:3
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