The effect of curculigoside on the expression of matrix metalloproteinase-1 in cultured human skin fibroblasts

被引：0
|
作者：
Song-Yi Lee
Mi-Ran Kim
Hong Seok Choi
Hyung-In Moon
Jin Ho Chung
Dong Gun Lee
Eun-Rhan Woo
机构：
[1] Chosun University,College of Pharmacy
[2] Seoul National University Hosipital,Department of Dermatology, Seoul National University College of Medicine, and Clinical research Institute
[3] Kyungpook National University,School of Life Sciences and Biotechnology, College of Natural Sciences
来源：
Archives of Pharmacal Research | 2009年 / 32卷
关键词：
G.; Amaryllidaceae; Phenolic glycoside; Curculigoside; Cycloartane saponin; Matrix metalloproteinase-1; Type-1 procollagen;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The dried rhizomes of Curculigo orchioides G. yielded two phenolic glycosides, curculigoside (1), orcinol-β-D-glucoside (4), and two cycloartane saponins, curculigosaponin G (2), curculigosaponin I (3). The structures were determined using spectroscopic methods. Among these isolates, compound 1 exhibited potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts. In addition, it increased the level of Bcl-2 protein expression and decreased the level of Bax protein expression. Compound 4 was isolated from this plant for the first time.
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页码：1433 / 1439
页数：6
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