Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation

被引：12
|
作者：
Yao, Nianhuan [1 ]
Fung, Gabriel [1 ]
Malekan, Hamed [2 ]
Ye, Long [2 ]
Kurth, Mark J. [2 ]
Lam, Kit S. [1 ]
机构：
[1] UC Davis Canc Ctr, Sch Med, Dept Internal Med, Div Hematol & Oncol, Sacramento, CA 95817 USA
[2] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA
来源：
CARBOHYDRATE RESEARCH | 2010年 / 345卷 / 15期
关键词：
Fmoc amino acids; Glycosylation; Microwave irradiation; SOLID-PHASE SYNTHESIS; PEPTIDE TEMPLATES; GLYCOPEPTIDES;
D O I：
10.1016/j.carres.2010.07.040
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of glycosylated Fmoc amino acids by reaction of mono- and disaccharide peracetates with Fmoc amino acids having free carboxyl groups was rapidly promoted by Lewis acids (SnCl4, BF3 center dot Et2O) under microwave irradiation. The products are useful building blocks for the synthesis of glycopeptides. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2277 / 2281
页数：5
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