The Biological Effect of Small Extracellular Vesicles on Colorectal Cancer Metastasis

被引：3

作者：

Wang, Xiaoxing ^{[1
,2
]}

Huang, Defa ^{[1
,2
]}

Wu, Jiyang ^{[1
,2
]}

Li, Zhengzhe ^{[1
,2
]}

Yi, Xiaomei ^{[1
,2
]}

Zhong, Tianyu ^{[1
,2
]}

机构：

[1] Gannan Med Univ, Sch Clin Med 1, Ganzhou 341000, Peoples R China

[2] Gannan Med Univ, Affiliated Hosp 1, Lab Med, Ganzhou 341000, Peoples R China

来源：

CELLS | 2022年 / 11卷 / 24期

基金：

中国国家自然科学基金;

关键词：

colorectal cancer; small extracellular vesicles; tumor microenvironment; angiogenesis; metastasis; VASCULAR-PERMEABILITY; PROMOTES INVASION; LIVER METASTASIS; DOWN-REGULATION; CELL; EXOSOMES; EMT; MACROPHAGES; PROGRESSION; CROSSTALK;

D O I：

10.3390/cells11244071

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Colorectal cancer (CRC) is a malignancy that seriously threatens human health, and metastasis from CRC is a major cause of death and poor prognosis for patients. Studying the potential mechanisms of small extracellular vesicles (sEVs) in tumor development may provide new options for early and effective diagnosis and treatment of CRC metastasis. In this review, we systematically describe how sEVs mediate epithelial mesenchymal transition (EMT), reconfigure the tumor microenvironment (TME), modulate the immune system, and alter vascular permeability and angiogenesis to promote CRC metastasis. We also discuss the current difficulties in studying sEVs and propose new ideas.

引用

页数：14

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