Apoptosis and metastasis: A superior resistance of metastatic cancer cells to programmed cell death

被引：110
|
作者：
Glinsky, GV
Glinsky, VV
机构：
[1] UNIV MISSOURI, DEPT BIOCHEM, COLUMBIA, MO 65201 USA
[2] METASTAT INC, COLUMBIA, MO 65201 USA
来源：
CANCER LETTERS | 1996年 / 101卷 / 01期
关键词：
metastasis; apoptosis; homotypic cell aggregation;
D O I：
10.1016/0304-3835(96)04112-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We studied the response to different external signals leading to apoptosis of several poorly and highly metastatic cell lines employing a murine B16 melanoma experimental metastasis model. We found that highly metastatic cells exhibit a superior survival ability and resistance to apoptosis compared to poorly metastatic cells which would give the former an obvious selective growth advantage during tumor progression. Our results indicate that there is a genetic link between aggressive metastatic phenotype and resistance to apoptosis.
引用
收藏
页码：43 / 51
页数：9
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