dabPNA:: Design, synthesis, and DNA binding studies

被引：29

作者：

Roviello, Giovanni N. ^{[1
]}

Musumeci, Domenica ^{[1
]}

Moccia, Maria ^{[1
]}

Castiglione, Mariangela ^{[1
]}

Sapio, Roberto ^{[2
]}

Valente, Margherita ^{[2
]}

Bucci, Enrico M. ^{[2
]}

Perretta, Giuseppe ^{[1
]}

Pedone, Carlo ^{[1
]}

机构：

[1] CNR, Inst Biostutture & Bioimmagini, I-80134 Naples, Italy

[2] Bionucleon Srl, Colleretto Giacosa, TO, Italy

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2007年 / 26卷 / 10-12期

关键词：

DABA; nucleopeptides; binding studies;

D O I：

10.1080/15257770701530640

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In continuing our research efforts for developing new oligodeoxynucleotide (ODN)-like drugs and diagnostics, we designed diaminobutyric peptide nucleic acids (dabPNAs), nucleopeptides characterized by a diaminobutyric-based building block that is an isomer of the aminoethylglycyl PNA (aegPNA) unit and the acyclic modification of the aminoprolyl PNA (ampPNA) monomer. In this work we present the solid phase synthesis of a dabPNA oligomer and of two aegPNAs containing a single dabPNA unit. A study relative to their binding ability towards DNA is also reported even in comparison with the well known aegPNAs.

引用

页码：1307 / 1310

页数：4

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