Exosomes as an Exciting Class of a Next-Generation Therapeutic Platform and their Role in Diagnostics

被引:0
|
作者
Bobade, Sumedha [1 ]
Vijayarani, K. [1 ]
Timurugaan, K. G. [1 ]
Thangavelu, A. [1 ]
Vairamuthu, S. [1 ]
Kalaiseivi, G. [1 ]
机构
[1] Tamil Nadu Vet & Anim Sci Univ, Madras Vet Coll, Dept Anim Biotechnol, Chennai, Tamil Nadu, India
来源
关键词
BIOGENESIS; CARGOS; ESCRT; MVBS; NANOCARRIER; EXTRACELLULAR VESICLES; DELIVERY VEHICLES; BIOGENESIS; BIOMARKERS; SECRETION; RECEPTOR; CELLS;
D O I
10.21786/bbrc/12.4/36
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Exosomes are nanovesicles and is a newly emerging field as a novel form of information exchange in various fields of research. Exosomes are a next-generation therapeutic platform and their role in diagnostics acts as a potential vehicle to deliver therapies to cells of the body, as they are rich in cargos like proteins and nucleic acids. Cargo trafficking provides an opportunity to become effective therapeutic reagents for various diseases, like cancer and are also used as biomarkers for the diagnosis. Exosomes are released in biological fluids, such as plasma, serum, urine, and saliva. The present review article provides a comprehensive account on exosome biogenesis, extraction, and (heir potential use in diagnostics, therapeutic, neurodegenerative disease diagnosis as well as highly precious biomedical tools and their roles in therapeutic vehicles for drug delivery. In future as the field rapidly expands, the different exosome cargos can be used as potential biomarkers which can revolutionize the area of personalized medicine.
引用
收藏
页码:1123 / 1133
页数:11
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