Clozapine-induced type-2 diabetes mellitus: possible mechanisms and implications for clinical practice

被引：9
|
作者：
Tovey, E
Rampes, H
Livingstone, C
机构：
[1] Barnet Enfield & Haringey Mental Hlth NHS Trust, NW Community Mentel Hlth Team, Edgware HA8 7BJ, Middx, England
[2] Royal Surrey Cty Hosp, Dept Clin Biochem, Guildford, Surrey, England
来源：
JOURNAL OF PSYCHOPHARMACOLOGY | 2005年 / 19卷 / 02期
关键词：
adverse effect; antipsychotic; clozapine; diabetes mellitus; schizoaffective disorder; schizophrenia;
D O I：
10.1177/0269881105049043
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The atypical antipsychotic clozapine has been reported to be associated with metabolic adverse effects, including type-2 diabetes mellitus. We present two cases of diabetes mellitus associated with clozapine treatment. One case resolved entirely upon withdrawal of the drug, whereas the other did not. We discuss the molecular basis of the diabetogenic action of clozapine and recommendations for monitoring.
引用
收藏
页码：207 / 210
页数：4
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