Using Time-of-Flight Secondary Ion Mass Spectrometry to Study Biomarkers

被引：39

作者：

Thiel, Volker ^{[1
]}

Sjovall, Peter ^{[2
]}

机构：

[1] Univ Gottingen, Geosci Ctr, Geobiol Grp, D-37077 Gottingen, Germany

[2] SP Tech Res Inst Sweden, SE-50115 Boras, Sweden

来源：

ANNUAL REVIEW OF EARTH AND PLANETARY SCIENCES, VOL 39 | 2011年 / 39卷

关键词：

biosignatures; geobiology; geomicrobiology; hydrocarbons; lipids; ToF-SIMS; BEARING FLUID INCLUSIONS; TOF-SIMS ANALYSIS; MORPHOLOGICAL BIOSIGNATURES; BIOLOGICAL SAMPLES; MALDI-TOF; CHEMICAL-COMPOSITION; CLUSTER BOMBARDMENT; ANAEROBIC OXIDATION; TISSUE-SECTIONS; LIPID BIOMARKER;

D O I：

10.1146/annurev-earth-040610-133525

中图分类号：

P1 [天文学];

学科分类号：

0704 ;

摘要：

Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a technique designed to analyze the composition and spatial distribution of molecules and chemical structures on surfaces. These capabilities have generated much interest in its use in geobiology, in particular for the characterization of organic biomarkers (molecular biosignatures) at the microscopic level. We here discuss the strengths, weaknesses, and potential of ToF-SIMS for biomarker analyses with a focus on applications in geobiology, including biogeochemistry, organic geochemistry, geomicrobiology, and paleobiology. After describing the analytical principles of ToF-SIMS, we discuss issues of biomarker spectral formation and interpretation. Then, key applications of ToF-SIMS to soft (microbial matter, cells), hard (microbial mineral precipitates), and liquid (petroleum) samples relevant in geobiology are reviewed. Finally, we examine the potential of ToF-SIMS in biomarker research and the current limitations and obstacles for which further development would be beneficial to the field.

引用

页码：125 / 156

页数：32

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