Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus

被引：159

作者：

Patterson, S

Rae, A

Hockey, N

Gilmour, J

Gotch, F

机构：

[1] Chelsea & Westminster Hosp, Imperial Coll, Sch Med, Dept Immunol, London SW10 9NH, England

[2] Imperial Canc Res Fund, Flow Cytometry Dept, Lincolns Inn Fields, London WC2A 3PX, England

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 14期

关键词：

D O I：

10.1128/JVI.75.14.6710-6713.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Plasmacytoid dendritic cells (pcDC) and myeloid dendritic cells (myDC) are shown to express CD4 and low levels of CCR5 and CXCR4, but only myDC express DC SIGN, a C-type lectin that binds human immunodeficiency virus but does not mediate virus entry. Both DC types were more susceptible to infection with a macrophage than a lymphotropic strain of human immunodeficiency virus type 1, but pcDC were more readily infected than myDC.

引用

页码：6710 / 6713

页数：4

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