Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus

被引：159
|
作者：
Patterson, S
Rae, A
Hockey, N
Gilmour, J
Gotch, F
机构：
[1] Chelsea & Westminster Hosp, Imperial Coll, Sch Med, Dept Immunol, London SW10 9NH, England
[2] Imperial Canc Res Fund, Flow Cytometry Dept, Lincolns Inn Fields, London WC2A 3PX, England
来源：
JOURNAL OF VIROLOGY | 2001年 / 75卷 / 14期
关键词：
D O I：
10.1128/JVI.75.14.6710-6713.2001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Plasmacytoid dendritic cells (pcDC) and myeloid dendritic cells (myDC) are shown to express CD4 and low levels of CCR5 and CXCR4, but only myDC express DC SIGN, a C-type lectin that binds human immunodeficiency virus but does not mediate virus entry. Both DC types were more susceptible to infection with a macrophage than a lymphotropic strain of human immunodeficiency virus type 1, but pcDC were more readily infected than myDC.
引用
收藏
页码：6710 / 6713
页数：4
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