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Impact of allogeneic hematopoietic cell transplantation on the outcome of older patients with acute myeloid leukemia

被引：19
|
作者：
Appelbaum, Frederick R. [1 ,2 ]
机构：
[1] Univ Washington, Div Med Oncol, Sch Med, 1100 Fairview Ave North, Seattle, WA 98109 USA
[2] Fred Hutchinson Canc Res Ctr, 1100 Fairview Ave North, Seattle, WA 98109 USA
来源：
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2017年 / 30卷 / 04期
关键词：
Allogeneic; Acute myeloid leukemia; AML; Elderly; HET; Hematopoietic cell transplant; 1ST COMPLETE REMISSION; CONVENTIONAL CARE REGIMENS; AZACITIDINE; AML; AGE;
D O I：
10.1016/j.beha.2017.09.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
For younger patients with intermediate- or high-risk acute myeloid leukemia (AML) in first remission, allogeneic hematopoietic cell transplantation (HCT) offers the best chance of cure and therefore is the treatment of choice. The role of allogeneic HCT in the treatment of older patients is less well defined. In this review, four issues concerning the role of HCT in the treatment of older AML patients will be addressed: the frequency of allogeneic HCT in the older AML population in the US; the impact of age on the outcome of HCT; the comparative outcome of allogeneic HCT versus chemotherapy in older AML patients; and some of the barriers to the effective use of HCT in older AML patients. (C) 2017 Published by Elsevier Ltd.
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页码：320 / 326
页数：7
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