Impact of allogeneic hematopoietic cell transplantation on the outcome of older patients with acute myeloid leukemia

被引：19
|
作者：
Appelbaum, Frederick R. [1 ,2 ]
机构：
[1] Univ Washington, Div Med Oncol, Sch Med, 1100 Fairview Ave North, Seattle, WA 98109 USA
[2] Fred Hutchinson Canc Res Ctr, 1100 Fairview Ave North, Seattle, WA 98109 USA
来源：
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2017年 / 30卷 / 04期
关键词：
Allogeneic; Acute myeloid leukemia; AML; Elderly; HET; Hematopoietic cell transplant; 1ST COMPLETE REMISSION; CONVENTIONAL CARE REGIMENS; AZACITIDINE; AML; AGE;
D O I：
10.1016/j.beha.2017.09.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
For younger patients with intermediate- or high-risk acute myeloid leukemia (AML) in first remission, allogeneic hematopoietic cell transplantation (HCT) offers the best chance of cure and therefore is the treatment of choice. The role of allogeneic HCT in the treatment of older patients is less well defined. In this review, four issues concerning the role of HCT in the treatment of older AML patients will be addressed: the frequency of allogeneic HCT in the older AML population in the US; the impact of age on the outcome of HCT; the comparative outcome of allogeneic HCT versus chemotherapy in older AML patients; and some of the barriers to the effective use of HCT in older AML patients. (C) 2017 Published by Elsevier Ltd.
引用
收藏
页码：320 / 326
页数：7
相关论文
共 50 条
  • [1] Effectiveness of allogeneic hematopoietic cell transplantation for older patients with acute myeloid leukemia
    Appelbaum, Frederick R.
    [J]. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2021, 34 (04)
  • [2] Allogeneic Hematopoietic Stem Cell Transplantation for Older Patients With Acute Myeloid Leukemia
    Levin-Epstein, Rebecca
    Oliai, Caspian
    Schiller, Gary
    [J]. CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2018, 19 (12)
  • [3] Allogeneic Hematopoietic Stem Cell Transplantation for Older Patients With Acute Myeloid Leukemia
    Rebecca Levin-Epstein
    Caspian Oliai
    Gary Schiller
    [J]. Current Treatment Options in Oncology, 2018, 19
  • [4] Allogeneic Hematopoietic Cell Transplantation for Older Adults with Acute Myeloid Leukemia
    Lipof, Jodi J.
    Loh, Kah Poh
    O'Dwyer, Kristen
    Liesveld, Jane L.
    [J]. CANCERS, 2018, 10 (06)
  • [5] Allogeneic hematopoietic cell transplantation for acute myeloid leukemia in older adults
    Sorror, Mohamed L.
    Estey, Elihu
    [J]. HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 2014, : 21 - 33
  • [6] OUTCOME OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN 30 ACUTE MYELOID LEUKEMIA PATIENTS AGED 60 YEARS OR OLDER
    Candoni, A.
    Simeone, E.
    Sperotto, A.
    Tiribelli, M.
    Geromin, A.
    Cerno, M.
    Patriarca, F.
    Battista, M.
    Fanin, R.
    [J]. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 : 294 - 295
  • [7] Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia
    Vyas, Paresh
    Appelbaum, Frederick R.
    Craddock, Charles
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2015, 21 (01) : 8 - 15
  • [8] Allogeneic hematopoietic cell transplantation in acute myeloid leukemia
    Magee, Gray
    Ragon, Brittany Knick
    [J]. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2023, 36 (02)
  • [9] Allogeneic hematopoietic cell transplantation for patients with acute myeloid leukemia not in remission
    Yanada, Masamitsu
    Yamasaki, Satoshi
    Kondo, Tadakazu
    Kawata, Takahito
    Harada, Kaito
    Uchida, Naoyuki
    Doki, Noriko
    Yoshihara, Satoshi
    Katayama, Yuta
    Eto, Tetsuya
    Tanaka, Masatsugu
    Takada, Satoru
    Kawakita, Toshiro
    Nishida, Tetsuya
    Ota, Shuichi
    Serizawa, Kentaro
    Onizuka, Makoto
    Kanda, Yoshinobu
    Fukuda, Takahiro
    Atsuta, Yoshiko
    Konuma, Takaaki
    [J]. LEUKEMIA, 2024, 38 (03) : 513 - 520
  • [10] Nonmyeloablative Allogeneic Hematopoietic Cell Transplantation in Patients With Acute Myeloid Leukemia
    Gyurkocza, Boglarka
    Storb, Rainer
    Storer, Barry E.
    Chauncey, Thomas R.
    Lange, Thoralf
    Shizuru, Judith A.
    Langston, Amelia A.
    Pulsipher, Michael A.
    Bredeson, Christopher N.
    Maziarz, Richard T.
    Bruno, Benedetto
    Petersen, Finn B.
    Maris, Michael B.
    Agura, Edward
    Yeager, Andrew
    Bethge, Wolfgang
    Sahebi, Firoozeh
    Appelbaum, Frederick R.
    Maloney, David G.
    Sandmaier, Brenda M.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (17) : 2859 - 2867
12345