Delta Lactate (Three-hour Lactate Minus Initial Lactate) Prediction of In-hospital Death in Sepsis Patients

被引：6

作者：

Webb, Amanda L. ^{[1
]}

Kramer, Nicholas ^{[1
]}

Rosario, Javier ^{[1
]}

Dub, Larissa ^{[1
]}

Lebowitz, David ^{[1
]}

Amico, Kendra ^{[1
]}

Leon, Leoh ^{[1
]}

Stead, Tej G. ^{[2
]}

Vera, Ariel ^{[3
,4
]}

Ganti, Latha ^{[5
,6
,7
]}

机构：

[1] Univ Cent Florida, Coll Med, Emergency Med, Orlando, FL 32816 USA

[2] Brown Univ, Emergency Med, Providence, RI 02912 USA

[3] Univ Cent Florida, Hosp Corp Amer Grad Med Educ Consortium Greater, Coll Med, Emergency Med, Kissimmee, FL USA

[4] Osceola Reg Med Ctr, Emergency Med, Kissimmee, FL USA

[5] Envis Physician Serv, Emergency Med, Nashville, TN 37215 USA

[6] Univ Cent Florida, Hosp Corp Amer Grad Med Educ Consortium Greater O, Coll Med, Emergency Med, Orlando, FL 32816 USA

[7] Polk Cty Fire Rescue, Emergency Med Serv, Bartow, FL 33830 USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2020年 / 12卷 / 04期

关键词：

sepsis; lactate; SEPTIC SHOCK; MORTALITY; EPIDEMIOLOGY; THERAPY;

D O I：

10.7759/cureus.7863

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study examines the relationship between serial serum lactate levels and in-hospital mortality in an adult cohort of emergency department patients with severe sepsis or septic shock. Of the 164 patients in the cohort, 130 also got three-hour lactate in addition to the initial one. The median initial lactate was 3.01 (interquartile range [IQR]: 1.71-4.62). The median repeat lactate was 2.58 (IQR: 1.4-3.9). The in-hospital death rate was 23% for men and 29% for women. The delta lactate was significantly higher in women (P=0.0070), driven by a lower initial lactate (P=0.0277). In a multivariate regression model controlled for age and gender, a statistically significant correlation was noted between an increase in the delta lactate and in-hospital death (P=0.0323; R-2=11.3%). The results of this single-center study suggest that an increase in serum lactic acid is significantly associated with higher in-hospital death.

引用

页数：6

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