Natural products-based insecticidal agents 9. Design, semisynthesis and insecticidal activity of 28-acyloxy derivatives of toosendanin against Mythimna separata Walker in vivo

被引：19

作者：

Xu, Hui ^{[1
]}

Zhang, Jun-Liang ^{[1
]}

机构：

[1] NW A&F Univ, Coll Sci, Lab Pharmaceut Design & Synth, Yangling 712100, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Toosendanin; 28-Acyloxy derivatives; Semisynthesis; Insecticidal activity; ANTIFEEDANT; AZEDARACH; EXTRACTS; ESTERS;

D O I：

10.1016/j.bmcl.2011.02.031

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In continuation of our program aimed at the discovery and development of natural products-based insecticidal agents, twelve 28-acyloxy derivatives of toosendanin (2a-l) were semisynthesized and preliminarily evaluated their activity against the pre-third-instar larvae of Mythimna separata Walker in vivo at the concentration of 1 mg/mL. Some compounds exhibited the potent insecticidal activity. Especially compounds 2c and 2j displayed the more promising insecticidal activity than their natural precursor, toosendanin, a commercial insecticide derived from Melia azedarach at 1 mg/mL. In general, it indicated that the butanoyloxy or phenylacryloyloxy moiety at the 28-position of toosendanin was essential for the insecticidal activity. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1974 / 1977

页数：4

共 24 条

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