Nickel-catalyzed reductive cyclization of unactivated 1,6-enynes in the presence of organozinc reagents

被引：47

作者：

Chen, Mao ^{[1
]}

Weng, Yue ^{[1
]}

Guo, Mian ^{[1
]}

Zhang, Hua ^{[1
]}

Lei, Aiwen ^{[1
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 12期

关键词：

cyclization; enynes; nickel; organozinc reagents; synthetic methods;

D O I：

10.1002/anie.200704452

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Pyrrolidine and tetrahydrofuran derivatives were synthesized in a highly stereoselective manner through the Ni-catalyzed reduction of the title compounds under mild conditions (see scheme). The product of cyclization is initially associated with both a Ni and a Zn species, the removal of which by elimination and hydrolysis corresponds to the formal incorporation of dihydrogen. acac=acetylacetonate; R=alkyl, aryl; X=N, O. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2279 / 2282

页数：4

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