The impact of PARPs and ADP-ribosylation on inflammation and host-pathogen interactions

被引：141

作者：

Fehr, Anthony R. ^{[1
]}

Singh, Sasha A. ^{[2
]}

Kerr, Catherine M. ^{[1
]}

Mukai, Shin ^{[2
]}

Higashi, Hideyuki ^{[2
]}

Aikawa, Masanori ^{[2
,3
,4
]}

机构：

[1] Univ Kansas, Dept Mol Biosci, Lawrence, KS 66045 USA

[2] Harvard Med Sch, Ctr Interdisciplinary Cardiovasc Sci, Brigham & Womens Hosp, Cardiovasc Div, Boston, MA 02115 USA

[3] Harvard Med Sch, Ctr Excellence Vasc Biol, Brigham & Womens Hosp, Boston, MA 02115 USA

[4] IM Sechenov First Moscow State Med Univ, Dept Human Pathol, Minist Hlth, Moscow 119146, Russia

来源：

GENES & DEVELOPMENT | 2020年 / 34卷 / 5-6期

基金：

美国国家卫生研究院;

关键词：

ADP-ribosylation; PARP; atherosclerosis; host-pathogen interactions; immunity; inflammation; macrophage; vascular disease; FINGER ANTIVIRAL PROTEIN; POLY(ADP-RIBOSE) POLYMERASE 1; AGGRESSIVE LYMPHOMA FAMILY; STRAND RNA VIRUSES; B-CELL LYMPHOMAS; RIBOSE POLYMERASE; MACROPHAGE ACTIVATION; NUCLEOCAPSID PROTEIN; WIDE IDENTIFICATION; VIRAL REPLICATION;

D O I：

10.1101/gad.334425.119

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a highly conserved, fundamental posttranslational modification (PTM). PARP catalytic domains transfer the ADP-ribose moiety from NAD(+) to amino acid residues of target proteins, leading to monoor poly-ADP-ribosylation (MARylation or PARylation). This PTM regulates various key biological and pathological processes. In this review, we focus on the roles of the PARP family members in inflammation and host-pathogen interactions. Here we give an overview the current understanding of the mechanisms by which PARPs promote or suppress proinflammatory activation of macrophages, and various roles PARPs play in virus infections. We also demonstrate how innovative technologies, such as proteomics and systems biology, help to advance this research field and describe unanswered questions.

引用

页码：341 / 359

页数：19

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