PARPs and ADP-Ribosylation in Chronic Inflammation: A Focus on Macrophages

被引：4
|
作者：
Santinelli-Pestana, Diego V. [1 ]
Aikawa, Elena [1 ,2 ]
Singh, Sasha A. [1 ]
Aikawa, Masanori [1 ,2 ,3 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Ctr Interdisciplinary Cardiovasc Sci, Div Cardiovasc Med,Dept Med, Boston, MA 02115 USA
[2] Harvard Med Sch, Brigham & Womens Hosp, Ctr Excellence Vasc Biol, Div Cardiovasc Med,Dept Med, Boston, MA 02115 USA
[3] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA
来源：
PATHOGENS | 2023年 / 12卷 / 07期
基金：
美国国家卫生研究院;
关键词：
immunity; mass spectrometry; proteomics; ADP-ribosylation; poly(ADP-ribose) glycohydrolase; Diphtheria toxin-like ADP-ribosyltransferases; chronic infection; arboviruses; cardiovascular disease; emphysema; alcoholic liver disease; SARS-CoV-2; host-pathogen interactions; POLY(ADP-RIBOSE) POLYMERASE; 3-AMINOBENZAMIDE PROTECTS; EXPRESSION; IDENTIFICATION; ACTIVATION; DOMAINS; BINDING; VIRUS; TRANSLATION; CORONAVIRUS;
D O I：
10.3390/pathogens12070964
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aberrant adenosine diphosphate-ribose (ADP)-ribosylation of proteins and nucleic acids is associated with multiple disease processes such as infections and chronic inflammatory diseases. The poly(ADP-ribose) polymerase (PARP)/ADP-ribosyltransferase (ART) family members promote mono- or poly-ADP-ribosylation. Although evidence has linked PARPs/ARTs and macrophages in the context of chronic inflammation, the underlying mechanisms remain incompletely understood. This review provides an overview of literature focusing on the roles of PARP1/ARTD1, PARP7/ARTD14, PARP9/ARTD9, and PARP14/ARTD8 in macrophages. PARPs/ARTs regulate changes in macrophages during chronic inflammatory processes not only via catalytic modifications but also via non-catalytic mechanisms. Untangling complex mechanisms, by which PARPs/ARTs modulate macrophage phenotype, and providing molecular bases for the development of new therapeutics require the development and implementation of innovative technologies.
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收藏
页数：18
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