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Univ Fed Pernambuco, Biosci Ctr, Dept Physiol & Pharmacol, Ave Prof Moraes Rego 1235, BR-50670901 Recife, PE, Brazil Univ Fed Pernambuco, Biosci Ctr, Dept Physiol & Pharmacol, Ave Prof Moraes Rego 1235, BR-50670901 Recife, PE, Brazil