Limited Impact of Fc-dependent Functions on the Efficacy of the Anti-HIV-1 Broadly Neutralizing Antibody PGT121 in Macaques

被引：0
|
作者：
Parsons, Matthew [1 ]
Lee, Wen Shi [1 ]
Kristensen, Anne [1 ]
Amarasena, Thakshila [1 ]
Khoury, Georges [1 ]
Davenport, Miles [2 ]
Kent, Stephen [1 ]
机构：
[1] Univ Melbourne, Melbourne, Vic, Australia
[2] Kirby Inst, Kensington, NSW, Australia
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2018年 / 34卷
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
P20.03
引用
收藏
页码：339 / 339
页数：1
相关论文
共 44 条
  • [11] Structural Evolution of HIV-1 gp120 Glycan Recognition by the PGT121 Lineage of Potent Broadly Neutralizing Antibodies
    Garces, Fernando
    Sok, Devin
    Kong, Leopold
    McBride, Ryan
    Kim, Helen J.
    Saye-Francisco, Karen F.
    Julien, Jean-Philippe
    Hua, Yuanzi
    Cupo, Albert
    Moore, John P.
    Paulson, James C.
    Ward, Andrew B.
    Burton, Dennis R.
    Wilson, Ian A.
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2014, 30 : A66 - A66
  • [12] Peripheral Membrane Interactions Boost the Engagement by an Anti-HIV-1 Broadly Neutralizing Antibody
    Rujas, Edurne
    Caaveiro, Jose M. M.
    Insausti, Sara
    Garcia-Porras, Miguel
    Tsumoto, Kouhei
    Nieva, Jose L.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (13) : 5571 - 5583
  • [13] Safety, pharmacokinetics and antiviral activity of PGT121, a broadly neutralizing monoclonal antibody against HIV-1: a randomized, placebo-controlled, phase 1 clinical trial
    Kathryn E. Stephenson
    Boris Julg
    C. Sabrina Tan
    Rebecca Zash
    Stephen R. Walsh
    Charlotte-Paige Rolle
    Ana N. Monczor
    Sofia Lupo
    Huub C. Gelderblom
    Jessica L. Ansel
    Diane G. Kanjilal
    Lori F. Maxfield
    Joseph Nkolola
    Erica N. Borducchi
    Peter Abbink
    Jinyan Liu
    Lauren Peter
    Abishek Chandrashekar
    Ramya Nityanandam
    Zijin Lin
    Alessandra Setaro
    Joseph Sapiente
    Zhilin Chen
    Lisa Sunner
    Tyler Cassidy
    Chelsey Bennett
    Alicia Sato
    Bryan Mayer
    Alan S. Perelson
    Allan deCamp
    Frances H. Priddy
    Kshitij Wagh
    Elena E. Giorgi
    Nicole L. Yates
    Roberto C. Arduino
    Edwin DeJesus
    Georgia D. Tomaras
    Michael S. Seaman
    Bette Korber
    Dan H. Barouch
    Nature Medicine, 2021, 27 : 1718 - 1724
  • [14] Safety, pharmacokinetics and antiviral activity of PGT121, a broadly neutralizing monoclonal antibody against HIV-1: a randomized, placebo-controlled, phase 1 clinical trial
    Stephenson, Kathryn E.
    Julg, Boris
    Tan, C. Sabrina
    Zash, Rebecca
    Walsh, Stephen R.
    Rolle, Charlotte-Paige
    Monczor, Ana N.
    Lupo, Sofia
    Gelderblom, Huub C.
    Ansel, Jessica L.
    Kanjilal, Diane G.
    Maxfield, Lori F.
    Nkolola, Joseph
    Borducchi, Erica N.
    Abbink, Peter
    Liu, Jinyan
    Peter, Lauren
    Chandrashekar, Abishek
    Nityanandam, Ramya
    Lin, Zijin
    Setaro, Alessandra
    Sapiente, Joseph
    Chen, Zhilin
    Sunner, Lisa
    Cassidy, Tyler
    Bennett, Chelsey
    Sato, Alicia
    Mayer, Bryan
    Perelson, Alan S.
    deCamp, Allan
    Priddy, Frances H.
    Wagh, Kshitij
    Giorgi, Elena E.
    Yates, Nicole L.
    Arduino, Roberto C.
    DeJesus, Edwin
    Tomaras, Georgia D.
    Seaman, Michael S.
    Korber, Bette
    Barouch, Dan H.
    NATURE MEDICINE, 2021, 27 (10) : 1718 - +
  • [15] Anti-HIV-1 Neutralizing Antibody Gene Delivery to Rhesus Macaques and Rodents: A Novel Vaccination Approach
    Clark, K. Reed
    Zhang, Jianchao
    Montefiori, David C.
    Johnson, Philip R.
    MOLECULAR THERAPY, 2006, 13 : S226 - S226
  • [16] Enhancement of Antibody-Dependent Cellular Cytotoxicity and Phagocytosis in Anti-HIV-1 Human-Bovine Chimeric Broadly Neutralizing Antibodies
    Edwards, Jack M.
    Heydarchi, Behnaz
    Khoury, Georges
    Salazar-Quiroz, Natalia A.
    Gonelli, Christopher A.
    Wines, Bruce
    Hogarth, P. Mark
    Kristensen, Anne B.
    Parsons, Matthew S.
    Purcell, Damian F. J.
    JOURNAL OF VIROLOGY, 2021, 95 (13)
  • [17] Coadministration of CH31 Broadly Neutralizing Antibody Does Not Affect Development of Vaccine-Induced Anti-HIV-1 Envelope Antibody Responses in Infant Rhesus Macaques
    Dennis, Maria
    Eudailey, Joshua
    Pollara, Justin
    McMillan, Arthur S.
    Cronin, Kenneth D.
    Saha, Pooja T.
    Curtis, Alan D.
    Hudgens, Michael G.
    Fouda, Genevieve G.
    Ferrari, Guido
    Alam, Munir
    Van Rompay, Koen K. A.
    De Paris, Kristina
    Permar, Sallie
    Shen, Xiaoying
    JOURNAL OF VIROLOGY, 2019, 93 (05)
  • [18] Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans
    Julien, Jean-Philippe
    Sok, Devin
    Khayat, Reza
    Lee, Jeong Hyun
    Doores, Katie J.
    Walker, Laura M.
    Ramos, Alejandra
    Diwanji, Devan C.
    Pejchal, Robert
    Cupo, Albert
    Katpally, Umesh
    Depetris, Rafael S.
    Stanfield, Robyn L.
    McBride, Ryan
    Marozsan, Andre J.
    Paulson, James C.
    Sanders, Rogier W.
    Moore, John P.
    Burton, Dennis R.
    Poignard, Pascal
    Ward, Andrew B.
    Wilson, Ian A.
    PLOS PATHOGENS, 2013, 9 (05)
  • [19] Validation of a Triplex Pharmacokinetic Assay for Simultaneous Quantitation of HIV-1 Broadly Neutralizing Antibodies PGT121, PGDM1400, and VRC07-523-LS
    Wesley, Martina S.
    Chiong, Kelvin T.
    Seaton, Kelly E.
    Arocena, Christine A.
    Sawant, Sheetal
    Hare, Jonathan
    Hernandez, Kasey
    Rojas, Michelle
    Heptinstall, Jack
    Beaumont, David
    Crisafi, Katherine
    Nkolola, Joseph
    Barouch, Dan H.
    Sarzotti-Kelsoe, Marcella
    Tomaras, Georgia D.
    Yates, Nicole L.
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [20] Trispecific antibody against HIV-1 demonstrate anti-viral activity in vivo and have potent Fc-dependent effector functions
    Almasri, Cassandra
    Xu, Ling
    Dias, Joana
    Promsote, Wanwisa
    Wei, Ronnie
    Lord, Dana M.
    Rao, Ercole
    Beninga, Jochen
    Yang, Zhi-yong
    Pegu, Amarendra
    Mascola, John R.
    Nabel, Gary J.
    JOURNAL OF IMMUNOLOGY, 2020, 204 (01):
12345