Copy number variation and susceptibility to complex traits

被引：6

作者：

Canales, Cesar P. ^{[1
]}

Walz, Katherina ^{[1
]}

机构：

[1] Univ Miami, Miller Sch Med, John P Hussman Inst Human Genom, Miami, FL 33136 USA

来源：

EMBO MOLECULAR MEDICINE | 2011年 / 3卷 / 01期

关键词：

CNV susceptibility; gene dosage; phenotypic variability; DISEASE; MOUSE; MODEL;

D O I：

10.1002/emmm.201000111

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Copy number variations (CNV) within the genome are extremely abundant. In this closeup, Canales and Walz discuss how CNV are associated with normal variation, genomic disorders, genome evolution, adaptive traits and how the use of a novel screen described by Ermakova et al in this issue that is designed to identify human disease-relevant phenotypes associated with CNV in the mouse can help elucidating susceptibility or predisposition to diseases loci.

引用

页码：1 / 4

页数：4

共 50 条

[41] Advancements in copy number variation screening in herbivorous livestock genomes and their association with phenotypic traits
Liu, Xiaotong
Chen, Wenting
Huang, Bingjian
Wang, Xinrui
Peng, Yongdong
Zhang, Xinhao
Chai, Wenqiong
Khan, Muhammad Zahoor
Wang, Changfa
FRONTIERS IN VETERINARY SCIENCE, 2024, 10
[42] Copy Number Variation of the PIGY Gene in Sheep and Its Association Analysis with Growth Traits
Feng, Ziting
Li, Xinyu
Cheng, Jie
Jiang, Rui
Huang, Ruolan
Wang, Dingchuan
Huang, Yongzhen
Pi, Li
Hu, Linyong
Chen, Hong
ANIMALS, 2020, 10 (04):
[43] Copy number variation of the HPGDS gene in the Ashidan yak and its associations with growth traits
Huang, Chun
Ge, Fei
Ren, Wenwen
Zhang, Yongfeng
Wu, Xiaoyun
Zhang, Qiang
Ma, Xiaoming
Bao, Pengjia
Guo, Xian
Chu, Min
Yan, Ping
Liang, Chunnian
GENE, 2021, 772
[44] Copy number variation of the HPGDS gene in the Ashidan yak and its associations with growth traits
Huang, Chun
Ge, Fei
Ren, Wenwen
Zhang, Yongfeng
Wu, Xiaoyun
Zhang, Qiang
Ma, Xiaoming
Bao, Pengjia
Guo, Xian
Chu, Min
Yan, Ping
Liang, Chunnian
GENE, 2021, 772
[45] Genome-Wide Detection of Copy Number Variations and Evaluation of Candidate Copy Number Polymorphism Genes Associated With Complex Traits of Pigs
Zhang, Chunlei
Zhao, Jing
Guo, Yanli
Xu, Qinglei
Liu, Mingzheng
Cheng, Meng
Chao, Xiaohuan
Schinckel, Allan P.
Zhou, Bo
FRONTIERS IN VETERINARY SCIENCE, 2022, 9
[46] Copy number variation involving the late cornified envelope gene cluster from the epidermal differentiation complex is associated with psoriasis susceptibility
Lee, C. H.
Capon, F.
Younes, M.
Allen, M.
Burden, A. D.
Trembath, R. C.
Barker, J. N.
BRITISH JOURNAL OF DERMATOLOGY, 2009, 160 (04) : 922 - 922
[47] The Potential Role of PTPRD Gene Copy Number Variation in Susceptibility to Rheumatoid Arthritis.
Shim, Seung Cheol
Sheen, Donghyuk
Lim, Mi Kyoung
Park, Hyo
ARTHRITIS AND RHEUMATISM, 2012, 64 (10): : S182 - S182
[48] DNA copy number variation and cancer susceptibility: The Li-Fraumeni Syndrome paradigm
Shlien, Adam
Tabori, Uri
Baskin, Berivan
Rotin, Lianne
Marshall, Christian
Feuk, Lars
Hudgins, Louanne
Nichols, Kim
Scherer, Stephen
Ray, Peter
Malkin, David
CHROMOSOME RESEARCH, 2009, 17 : 11 - 12
[49] Copy Number Variation Burden on Asthma Subgenome in Normal Cohorts Identifies Susceptibility Markers
Vishweswaraiah, Sangeetha
Veerappa, Avinash M.
Mahesh, Padukudru A.
Jahromi, Sareh R.
Ramachandra, Nallur B.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 2015, 7 (03) : 265 - 275
[50] Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum
Heinberg, Adina
Siu, Edwin
Stern, Chaya
Lawrence, Elizabeth A.
Ferdig, Michael T.
Deitsch, Kirk W.
Kirkman, Laura A.
MOLECULAR MICROBIOLOGY, 2013, 88 (04) : 702 - 712

← 1 2 3 4 5 →