Synthesis of aminopyrrolo[1,2-a]thieno[3,2-e]pyrazine derivatives as serotoninergic 5-HT7 ligands

被引：3
|
作者：
Pave, Gregoire [1 ]
Lazar, Said [2 ]
Lesnard, Aurelien [3 ]
Rault, Sylvain [3 ]
Guillaumet, Gerald [1 ]
机构：
[1] Univ Orleans, CNRS, Inst Chim Organ & Analyt, UMR 6005, BP 6759, F-45067 Orleans, France
[2] Univ Hassan II Mohammedia, Lab Biochim Environm & Agroalimentaire, URAC 36, Mohammadia 20800, Morocco
[3] Univ Caen, FR CNRS 3038, CERMN EA 4258, F-14032 Caen, France
来源：
ARKIVOC | 2010年
关键词：
Serotonin; 5-HT(7)Rs ligands; affinity; aminopyrrolothienopyrazines; RECEPTOR ANTAGONIST SB-269970; POTENTIAL ANXIOLYTIC AGENTS; 3,4-DIHYDRO-3-AMINO-2H-1-BENZOPYRAN DERIVATIVES; HIGH-AFFINITY; PHARMACOPHORES; RELAXATION; EXPRESSION; AGONISTS; CLONING;
D O I：
10.3998/ark.5550190.0011.a11
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of piperazinopyrrolo[1,2-a]thieno[3,2-e]pyrazine derivatives were prepared and evaluated to determine their affinity for the 5-HT7 receptor. Various substitutions on piperazine were explored as well as replacement of the piperazine by other amines.
引用
收藏
页码：116 / 131
页数：16
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