Quinoline based Pd(II) complexes: Synthesis, characterization and evaluation of DNA/protein binding, molecular docking and in vitro anticancer activity

被引：21
|
作者：
Thirunavukkarasu, Thangavel [1 ]
Sparkes, Hazel A. [2 ]
Natarajan, Karuppannan [3 ]
机构：
[1] CBM Coll, Dept Chem, Coimbatore 641042, Tamil Nadu, India
[2] Univ Bristol, Dept Chem, Bristol BS8 1TS, Avon, England
[3] Bharathiar Univ, Dept Chem, Coimbatore 641046, Tamil Nadu, India
来源：
INORGANICA CHIMICA ACTA | 2018年 / 482卷
关键词：
Quinoline; Palladium(II) complex; DNA/protein binding; Cytotoxicity; PALLADIUM(II) COMPLEXES; PLATINUM(II) COMPLEXES; SERUM-ALBUMIN; DNA-BINDING; ACID; CYTOTOXICITY; COPPER(II); THIOSEMICARBAZONE; SUBSTITUTION; DERIVATIVES;
D O I：
10.1016/j.ica.2018.06.003
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Two new palladium(II) complexes from 2-methyl 4-amino quinoline were synthesized and characterized by analytical, spectroscopic and X-ray diffraction techniques. The binding affinity and binding mode of the ligand and mononuclear complexes toward CT-DNA/BSA were determined by spectrophotometric titrations. From the binding studies, it has been found that the complexes interact strongly with CT-DNA and BSA. An in vitro cytotoxicity study of the compounds against human lung (A-549) and breast (MCF-7) cancer cell lines indicted better cytotoxic effect.
引用
收藏
页码：229 / 239
页数：11
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