Quinoline based Pd(II) complexes: Synthesis, characterization and evaluation of DNA/protein binding, molecular docking and in vitro anticancer activity

Two new palladium(II) complexes from 2-methyl 4-amino quinoline were synthesized and characterized by analytical, spectroscopic and X-ray diffraction techniques. The binding affinity and binding mode of the ligand and mononuclear complexes toward CT-DNA/BSA were determined by spectrophotometric titrations. From the binding studies, it has been found that the complexes interact strongly with CT-DNA and BSA. An in vitro cytotoxicity study of the compounds against human lung (A-549) and breast (MCF-7) cancer cell lines indicted better cytotoxic effect.