The effects of Danggui-Shaoyao-San on neuronal degeneration and amyloidosis in mouse and its molecular mechanism for the treatment of Alzheimer's disease

被引：21
|
作者：
Yang, Cong [1 ,2 ]
Mo, You-Sheng [1 ,2 ]
Chen, Hui-Fang [1 ,2 ]
Huang, Yan-Hui [1 ,2 ]
Li, Shao-Ling [1 ,2 ]
Wang, Hong [1 ]
Huang, Shui-Qing [1 ,2 ]
Chang, Xiang [3 ]
Du, Qun [1 ]
Wang, Qi [1 ,2 ]
机构：
[1] Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, Guangzhou 510405, Guangdong, Peoples R China
[2] Guangzhou Univ Chinese Med, Inst Clin Pharmacol, Guangzhou 510405, Guangdong, Peoples R China
[3] Xian Hosp Tradit Chinese Med, Xian 710021, Shaanxi, Peoples R China
来源：
JOURNAL OF INTEGRATIVE NEUROSCIENCE | 2021年 / 20卷 / 02期
关键词：
Danggui-Shaoyao-San; Alzheimer's disease; Cognitive deficits; Amyloidosis; Lipoprotein receptor-related protein-1; RAGE; COGNITIVE DEFICITS; BETA; CLEARANCE; SYSTEMS;
D O I：
10.31083/j.jin2002025
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The abnormal deposition of the extracellular amyloid-beta peptide is the typical pathological hallmark of Alzheimer's disease. Strategies to reduce the amyloid-beta deposition effectively alleviate the neuronal degeneration and cognitive deficits of Alzheimer's disease. Danggui-Shaoyao-San has been considered a useful therapeutic agent known for the treatment of Alzheimer's disease. However, the mechanism of Danggui-Shaoyao-San for the treatment of Alzheimer's disease remains unclear. We investigated Danggui-Shaoyao-San's effect on amyloidosis and neuronal degeneration in an APP/PS1 mouse model. We found Danggui-Shaoyao-San alleviated the cognitive deficits in APP/PS1 mice. Additionally, Danggui-Shaoyao-San ameliorated the neuronal degeneration in these mice. Danggui-Shaoyao-San reduced the amyloidosis and amyloid-beta(1-42) deposition in APP/PS1 mouse brain and down-regulated the receptor for advanced glycation end products, and up-regulated the level of low-density lipoprotein receptor-related protein-1. However, the protein expression of the beta-amyloid precursor protein, beta-Secretase and presenilin-1 (PS1) in the amyloid-beta production pathway, and the expression of neprilysin and insulin-degrading enzyme in the amyloid-beta degradation pathway were not altered. Our findings collectively suggest that Danggui-Shaoyao-San could ameliorate the amyloidosis and neuronal degeneration of Alzheimer's disease, which may be associated with its up-regulation lipoprotein receptor-related protein-1 and down-regulation of the receptor for advanced glycation end products.
引用
收藏
页码：255 / 264
页数：10
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