Elvitegravir-Cobicistat-Emtricitabine-Tenofovir Alafenamide Single-tablet Regimen for Human Immunodeficiency Virus Postexposure Prophylaxis

被引：10

作者：

Gantner, Pierre ^{[1
,2
]}

Hessamfar, Mojgan ^{[3
]}

Souala, Mohamed Faouzi ^{[4
]}

Valin, Nadia ^{[5
]}

Simon, Anne ^{[6
]}

Ajana, Faiza ^{[7
]}

Bouvet, Elisabeth ^{[8
]}

Rouveix, Elisabeth ^{[9
]}

Cotte, Laurent ^{[10
]}

Bani-Sadr, Firouze ^{[11
]}

Hustache-Mathieu, Laurent ^{[12
]}

Lebrette, Marie-Gisele ^{[13
]}

Truchetet, Francois ^{[14
]}

Galempoix, Jean-Marie ^{[15
]}

Piroth, Lionel ^{[16
]}

Pellissier, Gerard ^{[17
]}

Muret, Patrice ^{[18
]}

Rey, David ^{[19
]}

机构：

[1] Strasbourg Univ, Hop Univ Strasbourg, Lab Mol Virol, Strasbourg, France

[2] Strasbourg Univ, INSERM, Strasbourg, France

[3] CHU Bordeaux, Hop St Andre, Serv Med Interne & Malad Infectieuses, Bordeaux, France

[4] CHU Pontchaillou, Serv Malad Infectieuses & Trop, Rennes, France

[5] Hop St Antoine, AP HP, Serv Malad Infectieuses & Trop, Paris, France

[6] Hop La Pitie Salpetriere, AP HP, Serv Med Interne & Immunol Clin, Paris, France

[7] Ctr Hosp Tourcoing, Serv Univ Malad Infectieuses & Voyageur, Tourcoing, France

[8] Hop Bichat Claude Bernard, AP HP, Serv Malad Infect, Paris, France

[9] Hop Ambroise Pare, AP HP, Serv Med Interne, Boulogne, France

[10] Hop Croix Rousse, Malad Infect & Trop, Lyon, France

[11] Hop Robert Debre, Unite Malad Infect & Trop, Reims, France

[12] Hop Jean Minjoz, Serv Malad Infect & Trop, Besancon, France

[13] Hop Tenon, AP HP, Serv Malad Infect & Trop, Paris, France

[14] Ctr Hosp Metz Thionville, Serv Dermatol, Metz, France

[15] Ctr Hosp Manchester, Serv Med Infect, Charleville Mezieres, France

[16] CHU Dijon, Dept Infectiol, Dijon, France

[17] Grp Etud Risque Exposit Soignants Agents Infectie, Paris, France

[18] Hop Jean Minjoz, INSERM, Lab Pharmacol Clin, Besancon, France

[19] Hop Univ Strasbourg, HIV Infect Care Ctr, Le Trait Union, Strasbourg, France

来源：

CLINICAL INFECTIOUS DISEASES | 2020年 / 70卷 / 05期

关键词：

HIV; postexposure prophylaxis; completion; adherence; adverse events; DISOPROXIL FUMARATE; HIV; ADHERENCE;

D O I：

10.1093/cid/ciz577

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated an elvitegravir-cobicistat-emtricitabine-tenofovir alafenamide single-tablet regimen for human immunodeficiency virus postexposure prophylaxis. The completion rate and adherence were good, and the tolerance was acceptable; no seroconversion was observed. We confirm that this regimen could be appropriate for postexposure prophylaxis.

引用

页码：943 / 946

页数：4

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