The Bruton's tyrosine kinase inhibitor ibrutinib abrogates bispecific antibody-mediated T-cell cytotoxicity

被引：4
|
作者：
Godwin, Colin D. [1 ,2 ]
Bates, Olivia M. [1 ]
Garling, Eliotte E. [1 ]
Beddoe, Mary E. [1 ]
Laszlo, George S. [1 ]
Walter, Roland B. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Washington, Fred Hutchinson Canc Res Ctr, Clin Res Div, Seattle, WA 98195 USA
[2] Univ Washington, Dept Med, Div Hematol, Seattle, WA 98195 USA
[3] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
[4] Univ Washington, Dept Pathol, Seattle, WA 98195 USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2020年 / 189卷 / 01期
基金：
美国国家卫生研究院;
关键词：
acute leukaemia; bispecific antibody; Bruton's tyrosine kinase; ibrutinib; IL-2-inducible T-cell kinase;
D O I：
10.1111/bjh.16406
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：E9 / +
页数：5
相关论文
共 50 条
  • [41] Proarrhythmic Effects of Ibrutinib, a Clinically Approved Inhibitor of Bruton'S Tyrosine Kinase (BTK) Used in Cancer Therapy
    Yang, Tao
    Moslehi, Javid J.
    Roden, Dan M.
    CIRCULATION, 2015, 132
  • [42] Human antibody-mediated T-cell suppression for kidney transplantation
    Peter Sidaway
    Nature Reviews Nephrology, 2014, 10 (7) : 361 - 361
  • [43] Preliminary safety and efficacy of the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib (IBR) in patients (pts) with hairy cell leukemia (HCL).
    Jones, Jeffrey Alan
    Andritsos, Leslie A.
    Lucas, David M.
    Lozanski, Gerard
    Hutchinson, Terri
    Sexton, Jennifer L.
    Harris, Pamela Jo
    Grever, Michael R.
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [44] Dissecting the cellular and molecular players of T Cell Bispecific (TCB) antibody-mediated CRS
    Leclercq, Gabrielle
    Steinhoff, Nathalie
    Alberti-Serverra, LLucia
    Yanguez, Emilio
    Nassiri, Sina
    Giusti, Anna-Maria
    Schneider, Anneliese
    Klein, Christian
    Haegel, Helene
    Umana, Pablo
    Sam, Johannes
    Bacac, Marina
    CANCER RESEARCH, 2022, 82 (12)
  • [45] Beyond Bruton's tyrosine kinase inhibitors in mantle cell lymphoma: bispecific antibodies, antibody-drug conjugates, CAR T-cells, and novel agents
    Jain, Neeraj
    Mamgain, Mukesh
    Chowdhury, Sayan Mullick
    Jindal, Udita
    Sharma, Isha
    Sehgal, Lalit
    Epperla, Narendranath
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2023, 16 (01)
  • [46] RN486, a Selective Bruton's Tyrosine Kinase Inhibitor, Abrogates Immune Hypersensitivity Responses and Arthritis in Rodents
    Xu, Daigen
    Kim, Yong
    Postelnek, Jennifer
    Minh Diem Vu
    Hu, Dong-Qing
    Liao, Cheng
    Bradshaw, Mike
    Hsu, Jonathan
    Zhang, Jun
    Pashine, Achal
    Srinivasan, Dinesh
    Woods, John
    Levin, Anita
    O'Mahony, Alison
    Owens, Timothy D.
    Lou, Yan
    Hill, Ronald J.
    Narula, Satwant
    DeMartino, Julie
    Fine, Jay S.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2012, 341 (01): : 90 - 103
  • [47] Analysis of the Effects of the Bruton's tyrosine kinase (Btk) Inhibitor Ibrutinib on Monocyte Fcγ Receptor (FcγR) Function
    Ren, Li
    Campbell, Amanda
    Fang, Huiqing
    Gautam, Shalini
    Elavazhagan, Saranya
    Fatehchand, Kavin
    Mehta, Payal
    Stiff, Andrew
    Reader, Brenda F.
    Mo, Xiaokui
    Byrd, John C.
    Carson, William E., III
    Butchar, Jonathan P.
    Tridandapani, Susheela
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (06) : 3043 - 3052
  • [48] The Bruton's tyrosine kinase inhibitor ibrutinib exerts immunomodulatory effects through regulation of tumor-infiltrating macrophages
    Ping, Lingyan
    Ding, Ning
    Shi, Yunfei
    Feng, Lixia
    Li, Jiao
    Liu, Yalu
    Lin, Yufu
    Shi, Cunzhen
    Wang, Xing
    Pan, Zhengying
    Song, Yuqin
    Zhu, Jun
    ONCOTARGET, 2017, 8 (24) : 39218 - 39229
  • [49] IMMUNE INTERFERON MODULATION OF INVITRO MURINE ANTI-HUMAN T-CELL MONOCLONAL ANTIBODY-MEDIATED CYTOTOXICITY
    DILLMAN, RO
    JOHNSON, DE
    SHAWLER, DL
    JOURNAL OF IMMUNOLOGY, 1986, 136 (02): : 728 - 731
  • [50] Therapeutic effect of ibrutinib, a selective Bruton's tyrosine kinase inhibitor, in orbital fibroblasts from patients with Graves' orbitopathy
    Park, Hyun Young
    Chae, Min Kyung
    Ko, JaeSang
    Kikkawa, Don O.
    Jang, Sun Young
    Yoon, Jin Sook
    PLOS ONE, 2022, 17 (12):
12345