Eradication of hepatitis C virus 1b by interferon in a health care worker with acute hepatitis following needlestick transmission from a patient with chronic hepatitis C unresponsive to interferon

被引：6
|
作者：
Toyoda, H [1 ]
Sakamoto, H [1 ]
Mizuno, T [1 ]
Horiguchi, Y [1 ]
Nakano, H [1 ]
机构：
[1] Fujita Hlth Univ, Sch Med, Dept Gastroenterol, Aichi 4701192, Japan
来源：
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 2000年 / 35卷 / 10期
关键词：
acute hepatitis; eradication; hepatitis C virus genotype 1b; interferon;
D O I：
10.1080/003655200451270
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hepatitis C virus (HCV) was successfully eradicated by a short course of interferon (IFN) therapy in a nurse with acute HCV infection from a needlestick accident. The source patient had chronic hepatitis C and was a nonresponder to IFN therapy. The HCV genotype was Ib in patients, and a single point mutation (H-->R in amino acid 2218) was observed in the IFN sensitivity-determining region of the nonstructural 5A gene, in comparison with sequences of HCV-J, in HCV RNA from both the source patient (before and after IFN therapy) and the recipient (before IFN therapy). Though the strain transmitted was believed to be IFN-resistant in the patient with chronic hepatitis, the patient with acute hepatitis had a sustained response.
引用
收藏
页码：1117 / 1120
页数：4
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