Experimental model of C6 brain tumors in athymic rats

被引：7

作者：

Miura, Flavio K. ^{[1
]}

Alves, Maria Jose Ferreira ^{[1
]}

Rocha, Mussya Cisotto ^{[1
]}

Silva, Roseli S. ^{[1
]}

Oba-Shinjo, Sueli M. ^{[1
]}

Uno, M. ^{[1
]}

Colin, C. ^{[2
]}

Sogayar, M. C. ^{[2
]}

Marie, Sueli K. N. ^{[1
]}

机构：

[1] Univ Sao Paulo, Sch Med, Dept Neurol, Sao Paulo, Brazil

[2] Univ Sao Paulo, Inst Chem, Cell Mol Therapy Ctr, Sao Paulo, Brazil

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2008年 / 66卷 / 2A期

关键词：

brain tumor; C6; cells; experimental model; glioma;

D O I：

10.1590/S0004-282X2008000200019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Malignant brain tumor experimental models tend to employ cells that are immunologically compatible with the receptor animal. In this study, we have proposed an experimental model of encephalic tumor development by injecting C6 cells into athymic Rowett rats, aiming at reaching a model which more closely resembles to the human glioma tumor. In our model, we observed micro-infiltration of tumor cell clusters in the vicinity of the main tumor mass, and of more distal isolated tumor cells immersed in normal encephalic parenchyma. This degree of infiltration is superior to that usually observed in other C6 models.

引用

页码：238 / 241

页数：4

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