Efficient barrier protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells.

被引:0
|
作者
Feistritzer, C
Mosnier, LO
Di Cera, E
Griffin, JH
Riewald, M
机构
[1] Scripps Res Inst, Dept Immunol, La Jolla, CA USA
[2] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
[3] Washington Univ, Sch Med, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
28
引用
收藏
页码:13A / 13A
页数:1
相关论文
共 50 条
  • [31] Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier
    Deane, Rashid
    LaRue, Barbra
    Sagare, Abhay P.
    Castellino, Francis J.
    Zhong, Zhihui
    Zlokovic, Berislav V.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2009, 29 (01): : 25 - 33
  • [32] Protective effects of activated protein C in sepsis
    Toltl, Lisa J.
    Swystun, Laura L.
    Pepler, Laura
    Liaw, Patricia C.
    THROMBOSIS AND HAEMOSTASIS, 2008, 100 (04) : 582 - 592
  • [33] Zinc Binding to Protein C and Activated Protein C Modulates Their Interaction with Endothelial Cell Protein C Receptor
    Sen, Prosenjit
    Sahoo, Sanghamitra
    Pendurthi, Usha
    Rao, L. Vijaya Mohan
    BLOOD, 2009, 114 (22) : 140 - 140
  • [34] Signaling by activated protein C in endothelial cells is PAR1 dependent but distinct from thrombin signaling.
    Riewald, M
    Feistritzer, C
    Ruf, W
    BLOOD, 2004, 104 (11) : 67A - 67A
  • [35] Monocytes, but not endothelial cells, downregulate the anticoagulant activity of activated protein C
    Colucci, M
    Stramaglia, AM
    Mascolo, E
    Napoleone, E
    Lorenzet, R
    Semeraro, N
    BRITISH JOURNAL OF HAEMATOLOGY, 2001, 112 (02) : 519 - 526
  • [36] Porcine endothelial cells transgenic for human endothelial protein C receptor and/or thrombomodulin generate different levels of human activated protein C
    Bulato, C.
    Radu, C. M.
    Gavasso, S.
    Spiezia, L.
    Galli, C.
    Cozzi, E.
    Simioni, P.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 : 707 - 707
  • [37] Activation of endothelial cell protease activated receptor 1 by the protein C pathway
    Riewald, M
    Petrovan, RJ
    Donner, A
    Mueller, BM
    Ruf, W
    SCIENCE, 2002, 296 (5574) : 1880 - 1882
  • [38] Activated protein C stimulates osteoblast proliferation via endothelial protein C receptor
    Kurata, Tatsuya
    Hayashi, Tatsuya
    Yoshikawa, Tomoaki
    Okamoto, Takayuki
    Yoshida, Kakunoshin
    Iino, Takahiro
    Uchida, Atsumasa
    Suzuki, Koji
    THROMBOSIS RESEARCH, 2010, 125 (02) : 184 - 191
  • [39] Activated protein C attenuates thrombin-induced barrier dysfunction in human pulmonary artery endothelial cells via an endothelial protein C receptor-dependent mechanism.
    Finigan, JH
    Dudek, SM
    Singleton, PA
    Chiang, ET
    Camp, SM
    Ye, SQ
    Garcia, JGN
    JOURNAL OF INVESTIGATIVE MEDICINE, 2005, 53 (02) : S364 - S364
  • [40] Structural prediction and analysis of endothelial cell protein C/activated protein C receptor
    Villoutreix, BO
    Blom, AM
    Dahlbäck, B
    PROTEIN ENGINEERING, 1999, 12 (10): : 833 - 840