Nanoscale Metal-Organic Frameworks Decorated with Graphene Oxide for Magnetic Resonance Imaging Guided Photothermal Therapy

被引:26
|
作者
Meng, Jing [1 ]
Chen, Xiujin [1 ]
Tian, Yang [1 ]
Li, Zhongfeng [1 ]
Zheng, Qingfeng [2 ,3 ]
机构
[1] Capital Normal Univ, Beijing Key Lab Opt Mat & Photon Devices, Dept Chem, Beijing 100048, Peoples R China
[2] Chinese Acad Med Sci, Canc Hosp, Dept Thorac Surg, Natl Canc Ctr, Beijing 100021, Peoples R China
[3] Peking Union Med Coll, Beijing 100021, Peoples R China
基金
中国国家自然科学基金;
关键词
cancer; graphene; imaging agents; metal-organic frameworks; photochemistry; NEAR-INFRARED ABSORBENCY; CONTRAST AGENTS; DRUG-DELIVERY; CORE/SHELL NANOSTARS; CANCER-THERAPY; NANOPARTICLES; TUMORS; PLATFORM; MRI; NANOCOMPOSITES;
D O I
10.1002/chem.201702573
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Imaging-guided photothermal therapy (PTT) provides an attractive way to treat cancer. A composite material of a nanoscale metal-organic framework (NMOF) and graphene oxide (GO) has been prepared for potential use in tumor-guided PTT with magnetic resonance imaging (MRI). The NMOFs containing Fe3+ were prefabricated with an octahedral morphology through a solvothermal reaction to offer a strong T-2-weighted contrast in MRI. Then the NMOFs were decorated with GO nanosheets, which had good photothermal properties. After decoration, zeta-potential characterization shows that the aqueous stability of the composite material is enhanced, UV/Vis and near-infrared (NIR) spectra confirm that NIR absorption is also increased, and photothermal experiments reveal that the composite materials express higher photothermal conversion effects and conversion stability. The fabricated NMOF/GO shows low cytotoxicity, effective T-2-weighted contrast of MRI, and positive PTT behavior for a tumor model in vitro. The performance of the composite NMOF/GO for MRI and PTT was also tested upon injection into A549 tumor-bearing mice. The studies in vivo revealed that the fabricated NMOF/GO was efficient in T-2-weighted imaging and ablation of the A549 tumor with low cytotoxicity, which implied that the prepared composite contrast agent was a potential multifunctional nanotheranostic agent.
引用
收藏
页码:17521 / 17530
页数:10
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