Atrial Fibrillation and Risk of Cancer: A Danish Population-Based Cohort Study

Background-Atrial fibrillation (AF) and cancer are frequent diseases worldwide. The timewise association between the diagnosis of AF and a subsequent diagnosis of cancer may clarify whether a mutual cause exists, and may also guide clinicians about time windows of high risk of cancer occurrence. Methods and Results-We conducted a population-based cohort study among 26 222 men and 28 879 women free of AF and cancer at baseline based on the Danish Diet, Cancer and Health study. The participants were followed for the development of AF (the Danish National Patient Registry) and subsequent cancer (the Danish Cancer Registry) until 2013. We used Cox proportional hazard models with new-onset AF as time-dependent exposure. The men (median age 56 years) and women (median age 56 years) were followed for medians of 16.7 and 19.6 years, respectively. AF was associated with higher risks of any type of cancer (men: hazard ratio [HR] 1.41, 95% confidence interval [CI], 1.26-1.58; women: HR 1.15, 95% CI, 1.02-1.32), and for men only, lung (HR 1.66, 95% CI, 1.19-2.30), and colorectal cancer (HR 1.37, 95% CI, 1.02-1.85). Within the initial 90 days following the diagnosis of AF, the risks of any type of cancer (men: HR 2.89, 95% CI, 2.10-3.98; women: HR 3.72, 95% CI, 2.49-5.56), lung (men: HR 7.70, 95% CI, 4.34-13.68; women: HR 7.98, 95% CI, 3.96-16.09), and colorectal cancer (men: HR 3.35, 95% CI, 1.03-10.90; women: HR 5.91, 95% CI, 2.44-14.29) were higher for men and women. Conclusions-A diagnosis of AF is associated with a higher incidence rate of cancer among men and women. The cancer incidence rate is particularly elevated within 90 days after the diagnosis of AF.