Effects of naltrexone on electrocutaneous pain in patients with hypertension compared to normotensive individuals

被引：19
|
作者：
Ring, Christopher [1 ]
France, Christopher R. [2 ]
Al'Absi, Mustafa [3 ]
Edwards, Louisa [1 ]
McIntyre, David [1 ]
Carroll, Douglas [1 ]
Martin, Una [4 ]
机构：
[1] Univ Birmingham, Int Ctr Hlth & Ecercise Res, Birmingham B15 2TT, W Midlands, England
[2] Ohio Univ, Dept Psychol, Athens, OH 45701 USA
[3] Univ Minnesota, Sch Med, Dept Behav Sci, Duluth, MN 55812 USA
[4] Univ Birmingham, Sch Med, Wellcome Trust Clin Res Facil, Birmingham B15 2TT, W Midlands, England
来源：
BIOLOGICAL PSYCHOLOGY | 2008年 / 77卷 / 02期
关键词：
endogenous opioids; hypertension; hypoalgesia; naltrexone; pain;
D O I：
10.1016/j.biopsycho.2007.10.006
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
An opioid mechanism may help explain hypertensive hypoalgesia. A double-blind placebo-controlled design compared the effects of opioid blockade (naltrexone) and placebo on electrocutaneous pain threshold, pain tolerance, and retrospective McGill Pain Questionnaire ratings in 35 unmedicated patients with essential hypertension and 28 normotensive individuals. The hypertensives experienced less pain than normotensives during the assessment of their pain tolerance; however, this manifestation of hypertensive hypoalgesia was not moderated by naltrexone. These findings fail to support the hypothesis that essential hypertension is characterised by relative opioid insensitivity. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：191 / 196
页数：6
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