Interleukin-11 for treatment of hepatitis C-associated ITP

被引:8
|
作者
Fontana, Vincenzo [1 ]
Dudkiewicz, Pamela [1 ]
Jy, Wenche [1 ]
Horstman, Larry [1 ]
Ahn, Yeon S. [1 ]
机构
[1] Univ Miami, Miller Sch Med, Dept Med, Div Hematol Oncol,Wallace H Coulter Platelet Lab, Miami, FL 33136 USA
关键词
immune thrombocytopenic purpura; hepatitis C; interleukin-11;
D O I
10.1159/000125192
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Immune thrombocytopenic purpura (ITP) is frequently associated with chronic hepatitis C (HpC-ITP). Methods: Recombinant interleukin-11 (rIL-11), which has both thrombopoietic and anti-inflammatory properties, was evaluated in 12 patients with HpC-ITP in this pilot study. Group 1 (7 patients) was treated at high dose (50 mu g/kg daily) while group 2 (5 patients) at low dose (15-35 mu g/kg three/week). Results: In group 1, mean platelet counts rose from initial 54 x 10(9)/l to 103 x 10(9)/l (p = 0.02) and in group 2, from an initial 51 x 10(9)/l to 74 x 10(9)/l (p = 0.04). Antiplatelet antibody (aPlt-Ab) decreased in group 1. LFT improved in both groups. The mean HCV-RNA decreased in group 1 (p = 0.04), not in group 2. Side effects were common and troublesome, but were minimized with individualized dosing. One patient achieved good remission of both ITP and HpC lasting > 2 years with low-dose maintenance. Conclusion: When used based on individual tolerance, rIL-11 appears useful in HpC-ITP. Copyright (C) 2008 S. Karger AG, Basel.
引用
收藏
页码:126 / 132
页数:7
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