A One-Pot, Three-Component Approach to Functionalised Tetrahydroisoquinolines Using Domino Heck-aza-Michael Reactions

被引：16
|
作者：
Priebbenow, Daniel L. [1 ]
Pfeffer, Frederick M. [1 ]
Stewart, Scott G. [2 ]
机构：
[1] Deakin Univ, Sch Life & Environm Sci, Geelong, Vic 3217, Australia
[2] Univ Western Australia, Sch Biomed Biomol & Chem Sci, Crawley, WA 6009, Australia
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 09期
关键词：
Tetrahydroisoquinoline; Multicomponent reactions; Domino reactions; Heck reaction; Aza-Michael addition; Palladium; BISCHLER-NAPIERALSKI REACTION; STRUCTURE-BASED LIGANDS; MELANOCORTIN RECEPTORS; ISOQUINOLINE; CHEMISTRY; DC-52;
D O I：
10.1002/ejoc.201001621
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot, three-component method incorporating a domino Heck-aza-Michael reaction has been developed for the rapid synthesis of functionalised tetrahydroisoquinolines. Following the in situ generation of an acrylamide, a domino process involving intermolecular Heck reaction and subsequent intramolecular aza-Michael addition affords tetrahydroisoquinolines bearing C1-acetamide functionality.
引用
收藏
页码：1632 / 1635
页数：4
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