One-Pot, Three-Component Coupling Approach to the Synthesis of α-Iminocarboxamides

被引：17
|
作者：
Masui, Hisashi [1 ]
Fuse, Shinichiro [1 ]
Takahashi, Takashi [1 ]
机构：
[1] Tokyo Inst Technol, Dept Appl Chem, Meguro Ku, Tokyo 1528552, Japan
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 16期
关键词：
GLYCOSYL AMINO-ACIDS; ETHYLENE POLYMERIZATION; LITHIUM ALDIMINES; COMBINATORIAL SYNTHESIS; EFFICIENT SYNTHESIS; CARBONYL-COMPOUNDS; METALLO ALDIMINES; ORGANIC HALIDES; ISOCYANIDE; DERIVATIVES;
D O I：
10.1021/ol3017337
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot, three-component coupling was accomplished via the nucleophilic addition of an alkylsamarium(III) species to isocyanides and the subsequent addition of the resultant imidoyl samarium(III) species to isocyanates under mild conditions for the formation of alpha-iminocarboxamides. The developed sequential C-C bond-forming procedure enabled the rapid synthesis of the alpha-iminocarboxamides in good to excellent yields from readily available starting materials.
引用
收藏
页码：4090 / 4093
页数：4
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