Benzothiazoles: From recent advances in green synthesis to anti-cancer potential

According to World Health Organization Cancer is the second leading cause of death worldwide which accounted for an estimated 10.0 million deaths in 2020. Globally, the cancer burden is continuously growing, and it exerts tremendous physical, emotional, and financial strain on individuals, families, communities, and health systems. Looking at the stakes, researchers are vigorously trying to develop new anticancer agents. Recently, benzothiazole is emerging as one of the most active and interesting ingredients in the treatment against carcinoma cells but the problem lies with the complex multi-step processes implemented in pharmaceutical industries to synthesize target molecules as they produce a tremendous amount of waste. To prevail over the concerns of environmental agencies now focus has been shifted towards the synthesis of drugs using green reaction conditions. This work covers the recent advances in the green synthesis of benzothiazole scaffold along with its anticancer potential.